Proteins differentially expressed in the aging hippocampus

In their review of the “neuroproteome” associated with aging and cognitive decline, VanGuilder and Freeman discuss some of the technical approaches and findings in the field. This illustrative figure shows some of the major cellular players involved and lists some example proteins involved in four important pathways: As you can see, many proteins have been implicated, [...]

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Human gene expression database across ages and brain regions

The human brain transcriptome database contains genome-wide RNA expression data in various regions of 57 post-mortem human brains collected from “clinically unremarkable” donors across the lifespan. It is very easy to search for the expression patterns of a particular gene, and the output is easily interpreted. As an example, here are the results of a search for [...]

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Structural variability and the usefulness of understanding neural connectivity patterns

Two recent accounts from Jeff Lichtman about the technical progress in neural connectivity research can be found in his interview with Ira Glass, and his article with Winfried Denk. On a more philosophical note, the end of their article notes that: During the study of the mouse ear muscle described above, it became clear that every instantiation [...]

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